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For x linked genetic disorders In contrast, females have two x chromosomes and require two copies of a recessive allele to express the trait. The female with two x's can cancel out the x linked diseases on one of the chromosomes

The male only has one x and one y, thus the male cannot cancel out the x linked diseases, law of segregation. In females, the effect of the mutation may be masked by the second healthy copy of the x chromosome.

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